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KMID : 0043319920150010069
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Archives of Pharmacal Research
1992 Volume.15 No. 1 p.69 ~ p.72
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The Oxidative Iodination of Pyrimidine Bases and their Nucleosides using Iodine/Dimethylformamide/m-Chloroperbenzoic Acid
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Hwang CH
Park JS/Won JH/Kim JN/Ryu EK
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Abstract
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Pyrimidine bases and their nucleosides were oxidatively iodinated at C-5 position by the reaction of iodine in DMF (dimethylformamide) with MCPBA (m-chloroperbenzoic acid) under mild conditions. For uracil derivatives such as uracil 1a, 1,3-dimethyluracil 1b, uridine 1c, and 2’’-deoxyuridine 1d, the corresponding 5-iodo derivatives were obtained in high yields (71-95%). The iodination of cytidine 3a and 2’’-deoxycytidine 3b was achieved in moderate yields (41-56%).
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